Like this, but sadly much bigger.
When I started studying histo it was absolutely mystifying. Everything looked exactly the same, just a bunch of purple and pink blobs. The trick is in recognizing patterns, and key features. For example, the small intestine has three distinct regions which you can tell apart histologically; the duodenum, jejunum, and ileum. All of small intestine has simple columnar epithelium, which means the very outer layer of cells is sort of rectangular (best for absorption, makes sense right?), and all small intestine has big folds and dips (villi and crypts). Now, to tell the regions apart:
Duodenum: This one is the easiest, you see a bunch of Brunner's glands in the submucosa (the light purple little circles in the pink layer below all those folds)
Ileum is next easiest to identify because of the large Peyer's patches (lymphoid tissue). This is only tricky if you forget to search the entire length of the mucosa, because usually the patches are only on one side of the tissue.
Finally, jejunum. Actually I find this the trickiest, because of the Absence of any key identifying feature in the mucosa. If you are sure you're in small intestine, you know it's jejunum by the absence of Peyer's patches or Brunner's glands.
This is stomach, to give you an idea of the similarities between tissue.
And here are some of my favorite histology slides. They're quite pretty actually! And perhaps more importantly, easy to tell apart - a key requisite for my love):
Peripheral nerve
Pineal gland. Note the 'brand sand' (real term) on the lower left border. I think it looks like a geode
Thymus
They kind of look like abstract art!
ReplyDeleteOh I never thought of it like that, very true!
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